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It deals with semantically annotated literature for search and retrieval. By semantic annotation, we mean the linkage of regions of text (annotations) to concepts in ontologies. Semantic annotation is used to facilitate more complex search and retrieval; provide features for classification algorithms, such as trustability, readability, and provide linkage to biomedical knowledge resources. Once manual annotation has been done, feedback loops should be put in place to improve automatic annotation models and pattern grammars.